Weekend All Things Considered

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Guy Raz
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2:04pm

Wed January 2, 2013
Shots - Health News

Drug Fulfills Promise Of Research Into Cystic Fibrosis Gene

Originally published on Wed January 2, 2013 6:53 pm

Kalydeco is one of the first drugs that is effective at combating the root causes of a genetic disease.
Vertex Pharmaceuticals Inc.

The promise of genetic medicine is beginning to be fulfilled, but it's been a long, hard slog.

Take the story of Kalydeco. It's designed to treat people with a lung disease called cystic fibrosis. While not quite a cure, the drug is extremely effective for some CF patients.

But the success of Kalydeco has been more than two decades in the making.

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10:01am

Wed January 2, 2013
Asia

The Tony Soprano Of Karachi: Gangster Or Politician?

Originally published on Wed January 2, 2013 6:56 pm

Baloch has been the most powerful figure in Karachi's Lyari neighborhood since 2009. His armed men control the area, and police stay away. He's shown here at his home.
Dina Temple-Raston

Gangsters have been part of life in Karachi, Pakistan's largest city, for decades. And nowhere is their rule more notorious than in the slums of Lyari, a dusty warren of low-slung tenement houses in the south central part of Karachi.

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3:55pm

Tue January 1, 2013
Around the Nation

2013's New Laws Govern Driverless Cars, Employee Passwords

Originally published on Tue January 8, 2013 1:19 pm

Transcript

AUDIE CORNISH, HOST:

From NPR News, this is ALL THINGS CONSIDERED. I'm Audie Cornish. New laws go into effect across the country today and we're going to look at a few of them that all struggle with the same problem, how to keep up with technology. We're going to hear about three of them now from Jon Kuhl of the National Conference of State Legislatures. The first deals with that perplexing new phenomenon, driverless cars.

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3:24pm

Tue January 1, 2013
Shots - Health News

What The Health Law Will Bring In 2013

Originally published on Tue January 8, 2013 1:19 pm

The majority of what happens on Jan. 1, 2013, is tax increases and cuts in tax deductions to pay for the changes coming in 2014.
iStockphoto.com

Most of the really big changes made by the 2010 health law don't start for another year. That includes things like a ban on restricting pre-existing conditions, and required insurance coverage for most Americans. But Jan. 1, 2013, will nevertheless mark some major changes.

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3:16pm

Tue January 1, 2013
NPR Story

'Cliff' Deal Would End Payroll Tax Holiday

Originally published on Tue January 8, 2013 1:19 pm

Transcript

AUDIE CORNISH, HOST:

In covering this debate, much has been made of income tax rates and where exactly they should be raised. But one fact has gotten far less notice. Starting today, payroll taxes are going up two percentage points for nearly all American workers. NPR's John Ydstie joins us to talk about it. And John, this means lower take-home pay for a lot of workers starting very soon.

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